Preparation and application background and overview of 3-amino-5-methylpyridine
3-Amino-5-methylpyridine is a pyridine derivative. Pyridine and its derivatives are widely distributed in nature. Many plant ingredients such as alkaloids contain pyridine ring compounds in their structures. They are the basis for the production of many important compounds, such as medicines, pesticides, dyes, surfactants, rubber additives, feed additives, food additives, adhesives, etc. Indispensable raw materials in production. 3-Bromo-5-methylpyridine is an important intermediate in organic synthesis. It is mainly used in pharmaceutical intermediates, organic synthesis, and organic solvents. It can also be used in dye production, pesticide production, and spices.
Preparation and application of 3-amino-5-methylpyridine
Diethyl malonate reacts with sodium to form a salt, and then a toluene solution of 3-nitro-5-chloropyridine is added dropwise for condensation reaction, and then decarboxylated under acidic conditions to obtain 3-nitro-5-methylpyridine; The molar ratio of diethyl malonate, alkali metal, methoxyphenylboronic acid 3-nitro-5-chloropyridine is 6:1.3:1; 3-nitro-5-methylpyridine in Pd/C Under catalysis, methanol is used as the solvent, hydrogenation is reduced, suction filtration is performed, and the filtrate is concentrated to obtain 3-amino-5-methylpyridine.
Preparation and application of 3-amino-5-methylpyridine
3-Amino-5-methylpyridine first forms a salt with acid, cools to -10°C, adds liquid bromine dropwise, and then adds sodium nitrite aqueous solution dropwise. After the dropwise addition, adjust the pH of the solution to alkaline, and then proceed. Extract, dry and concentrate to obtain chromium 3-bromo-5-picoline picolinate.
References
[1] [Invented in China] CN201710490472.3 A synthesis method of 3-bromo-5-methylpyridine
