The antibacterial activity of fosfomycin trometamol in the body is produced by fosfomycin. Its molecular structure is similar to that of phosphoenolpyruvate, through the 168 amide group of bacterial pyruvate-uracil diphosphate-B antioxidant Glucose transferase binds irreversibly, inhibits the early synthesis of bacterial cell walls and plays a bactericidal effect.
Antibacterial effect
Fosfomycin tromethamine is effective against both Gram-positive and Gram-negative bacteria. It has inhibitory effect, and its antibacterial spectrum includes Escherichia coli, dysentery, Citrobacter, Proteus, Serratia, Staphylococcus aureus and Pseudomonas aeruginosa.
Pharmacokinetics
Fosfomycin tromethamine is well absorbed after oral administration, has a high concentration in the liver and kidneys, and can be distributed in large amounts in other organs and tissue fluids. The plasma concentration of healthy people reaches the peak value 2 hours after taking this product at a dose of 50 mg/kg
(Cmax) is 356ug/ml, which is 4.4 times that of oral fosfomycin calcium, and the half-life is 3 hours. This product is mainly excreted by the kidneys in the form of unchanged drug. Adults take 3g of this product orally once (3g based on fosfomycin acid), and the urine bactericidal concentration can last for 48 hours.
Indications
Fosfomycin tromethamine can be used for lower urinary tract infections caused by pathogenic bacteria that are sensitive to this product, such as cystitis, urethritis, and intestinal infections. , skin and soft tissue infections, respiratory tract infections.
Usage and Dosage
Dissolve the antioxidant in appropriate amount of water and take it orally once every night before going to bed for three days
