Betamethasone sodium phosphate is mainly used for allergic and autoimmune inflammatory diseases. It is now mostly used for active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, etc. It is also used for the comprehensive treatment of certain infections.
Pharmacological effects
Adrenal/corticosteroid drugs. It has various pharmacological effects such as anti-inflammatory, anti-allergy and immune suppression. Anti-inflammatory effect: Glucocorticoids reduce and prevent tissue responses to inflammation, thereby reducing the manifestations of inflammation. Immunosuppressive effects: Prevent or inhibit cell-mediated immune responses, delayed allergic reactions.
Pharmacokinetics
After intramuscular injection of tamasone sodium phosphate twice a day, the blood concentration of diethanolamine reached the peak in 1 hour. The plasma protein binding rate of this product is lower than that of other corticosteroid drugs.
PVC resin
Usage and dosage
Intramuscular or intravenous injection: 2-20 mg per day, divided into doses.
Taboo
Contraindicated for those allergic to this product and other steroid hormones. Patients with the following diseases are generally not suitable for use. In special cases, the pros and cons should be weighed before use, but attention should be paid to the possibility of worsening of the condition: severe mental illness (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis surgery, fractures, trauma repair period , corneal ulcer.
Warning
Elderly patients taking glucocorticoids are prone to hypertension and diabetes. The use of glucocorticoids in elderly patients, especially postmenopausal women, can easily aggravate osteoporosis.
Notes
Induced infection: Under the action of hormones, infections that have been controlled can become active. The most common case is the recurrence of tuberculosis infection. The application of hormones in certain infections can reduce tissue damage, reduce exudation, and alleviate the symptoms of infection and poisoning, but it must be treated with effective antibiotics at the same time and changes in the condition must be closely observed.
Drugs for pregnant and lactating women
Drugs during pregnancy: Glucocorticoids can cross the placenta. Animal experimental studies have confirmed that administration during pregnancy can increase the incidence of embryonic cleft palate, placental insufficiency, spontaneous abortion and intrauterine growth retardation. In humans, pharmacological doses of glucocorticoids may increase the risk of placental insufficiency, neonatal weight loss, or stillbirth.
Side effects
Possible side effects of betamethasone sodium phosphate mainly include:
Edema of lower limbs.
Prone to bleeding.
Fainting tendency.
Abdominal or back pain.
Hypokalemia syndrome.
Gastrointestinal irritation (nausea, vomiting).
pancreatitis.
Peptic ulcer or perforation.
Avascular necrosis of the humeral or femoral head.
Osteoporosis and fractures.
Poor wound healing.
Psychiatric symptoms (euphoria, agitation, delirium, restlessness, etc.).
Acne.
Menstrual disorders.
Growth in children is inhibited.
Glaucoma, cataracts.
Fungi, Mycobacterium tuberculosis, Staphylococcus aureus.
Benign intracranial hypertension syndrome, impaired glucose tolerance, and exacerbation of diabetes mellitus.
For other adverse reactions, please read the drug instructions carefully.
