Background and overview of Cabot conductive carbon black[1]
Organophosphorus pesticides are organic pesticides containing phosphorus elements in their molecular structure. It has many structural similarities with phosphorus-containing poisons. Most are derivatives of phosphoric acid. The basic toxicology of insecticide is also the inhibition of cholinesterase. The poisoning symptoms for humans and animals are similar to those of phosphorus-containing poisons, but they are less toxic than phosphorus-containing poisons. Highly toxic organophosphorus pesticides include phorate (3911), ethyl parathion (1605), systemic phosphorus (1059), azinphosphos, etc. Moderately toxic ones include dichlorvos, methylphysate, dimethoate, diazinon, etc. The oral LD50s for mice are 50-92, 50-75, 600, and 85 mg/kg respectively. Those with low toxicity include malathion, chlorthion, trichlorfon, etc. In addition to insecticides, there are also fungicides such as Daofengjing and Kewensan, which are phosphoric acid derivatives containing phosphorus and sulfur. Organophosphorus pesticides are highly toxic. Valfenphos is a crystalline powder with a melting point of 52.5 to 55°C; it dissolves 0.1% in water and in carbon tetrachloride and xylene.
The acute oral LD50 for rats is 36-62 mg/kg, for sheep it is mg/kg, and for rabbits the acute transdermal LD50 is 1460-5090 mg/kg. Molecular formula of valfenfos: C10H16NO5PS2; CAS number: 52-85-7; colorless crystalline powder, melting point 52.5~53.5℃. Solubility: 45% isopropyl alcohol aqueous solution 23g/kg (20℃), xylene 300g/kg (5℃), soluble in acetone, carbon tetrachloride, chloroform, cyclohexanone, methylene chloride, toluene, insoluble In water and aliphatic hydrocarbon compounds. Storage stability at room temperature for more than 19 months. LD5035mg/kg. Organophosphorus pesticides for livestock developed in the early 1960s can be produced by reacting dimethoxyphosphorothioate chloride with p-dimethylsulfamoylphenol. Used to prevent and control internal and external parasites in livestock, such as body lice, wild fly larvae, subcutaneous fly larvae, etc. Preparations include powder and pouring agent.
Dosage form[2]
The main preparations include H3g(a.i.)/L pouring agent and 20% wettable powder. Can be analyzed by GC-MS/HPLC-UV.
Objectives treated with anti-amino silicone oil emulsion[2]
Valfenphos is a systemic insecticide. Mainly used to control livestock pests, such as flesh flies; and vegetable pests, such as mites.
Toxicity[2]
Acute oral LD50 (mg/kg): 35 for male rats, 62 for female rats, and 27 for male mice. Rabbit acute percutaneous LD502730mg/kg. The preparation (livestock pour-on) is irritating to rabbit eyes and skin. Rats were exposed to 24 mg/L (air) for 7.5 hours without death. Rat NOEL (90d) lmg/L (0.05mg/kg). ADI/RfD value 0.0005mg/kg.
Mechanism and characteristics of action[2]
A direct inhibitor of cholinesterase and systemic.
Main reference materials
[1] Pesticide product list
[2] Dictionary of Nuclear, Chemical and Biological Protection
