[Background and Overview][1][2]https://www.chemicalbook.com/%3C/p>
Colonoscopy is one of the most commonly used and effective examination methods for diagnosing, intervening and treating intestinal diseases, and is the gold standard for investigating and evaluating intestinal mucosa. In colonoscopy, the degree of intestinal cleanliness plays a decisive role in the effectiveness of colonoscopy. A clean intestine provides basic conditions for smooth diagnosis and treatment activities such as inserting a scope, observing the colon mucosa, accurately obtaining biopsy specimens, and removing polyps through colonoscopy, and the chance of local infection after surgery is low. The ideal bowel preparation should be safe and effective, have few side effects, be willing to be accepted by patients, and achieve the purpose of quickly cleaning the intestines. In addition to the degree of intestinal cleanliness related to the patient’s diet and the condition of the intestine itself, the accurate selection of intestinal cleaning methods plays an important role. https://www.chemicalbook.com/%3C/p>
Sodium phosphate salt is recognized by the U.S. Food and Drug Administration (FDA) as an over-the-counter drug and is widely used in clinical applications. Oral sodium phosphate solution as a bowel preparation drug is more effective and more acceptable to patients than other methods, including polyethylene glycol solutions. Sodium phosphate salt has a higher rate of excellent overall colon cleansing quality than polyethylene glycol Lomon titanium dioxide R996 electrolyte solution. The application of sodium phosphate salt in intestinal preparation has good microscopic cleaning effect, low incidence of adverse reactions, and the excellent rate of intestinal preparation reaches 96.7%. Because of its good taste and good patient tolerance, sodium phosphate oral solution bowel preparation method is more commonly used in Western countries, and has been widely used in colonoscopy, barium enema examination and preoperative bowel preparation. There are also reports of its use as an enema in China, and it is believed that it can reduce the patient’s discomfort and the occurrence of postoperative flora disorders, and reduce the damage to the intestinal barrier. At the same time, some studies found that the preoperative plasma D-lactate, diamine oxidase and endotoxin levels of patients in the sodium phosphate salt bowel preparation group were not significantly different from those in the traditional 3-day bowel preparation group. Therefore, it is believed that this is a preliminary explanation from the perspective of intestinal barrier function. Sodium phosphate bowel preparation is safe. https://www.chemicalbook.com/%3C/p>
[Specifications][3][4]https://www.chemicalbook.com/%3C/p>
Sodium phosphate oral solution: 90ml; enema: 133ml (usable volume 118ml)/bottle https://www.chemicalbook.com/%3C/p>
【Usage and Dosage】[3][4]https://www.chemicalbook.com/%3C/p>
One bottle per day for adults and children over 12 years old, one-time use; prohibited for children under 2 years old; children between 2 and 11 years old should use Children’s Huili Kaiser. This product should not be used more than once unless directed by a physician. Postures to use this product: Left side: Lie flat on the left side of your body, bend your right knee, and relax your arms naturally. Knee-chest position: Kneel on your knees, then tilt your head and chest downward until the left side of your face touches the surface of the object, and bend your left arm naturally. . The usage of this product is as follows: Take the orange protective cap on the bottle mouth and align the bottle mouth with the anus. Use steady pressure to gently insert the bottle mouth into the rectum. When inserting, gently turn the bottle clockwise or counterclockwise. If If you exert force, it is similar to defecation exercises and helps to relax the muscles around the anus. https://www.chemicalbook.com/%3C/p>
Oral time selection: There is no unified standard for the specific time to take laxatives during bowel preparation. Although bowel preparation drugs are constantly updated, people with insufficient bowel preparation still account for 10% to 75% of all colonoscopies. %. In foreign countries, the interval between using two bottles of sodium phosphate oral solution is usually 5 to 12 hours. There are also different opinions on the interval between use of sodium phosphate oral liquid in China, mostly between 2 and 12 hours. Foreign studies have pointed out that severe hyperphosphatemia will occur if more than 2 bottles are used or the interval between 2 bottles is less than 5 hours. Randomized controlled trials pointed out that the intestinal cleansing effect of sodium phosphate oral solution is negatively correlated with the time between the use of the first dose and the colonoscopy. A colonoscopy performed within 12 hours after taking the second dose will have a good effect, and the effect will be better within 6 hours. . Studies have found that bowel preparation performed on the same day is more effective than bowel preparation performed 1 day before. The sodium phosphate salt oral solution takes effect 30 minutes after oral administration and lasts for 2 to 3 hours. 83% of patients stopped violent intestinal activity within 4 hours after taking the second dose. The instructions for sodium phosphate oral liquid indicate that the two doses should be taken 12 hours apart or the second dose should be taken orally at least 3 hours before the examination. The rational use time and interval of sodium phosphate salts are still inconclusive, and more detailed randomized controlled trials are needed. https://www.chemicalbook.com/%3C/p>
[Indications][3][4]https://www.chemicalbook.com/%3C/p>
Oral liquid: used to clean the intestines before patients’ colon X-ray and intestinal endoscopy or surgery. https://www.chemicalbook.com/%3C/p>
Enema: Relieve occasional constipation and clean the intestines before rectal examination. https://www.chemicalbook.com/%3C/p>
[4] https://www.chemicalbook.com/%3C/p>
[5] Liu Jian; Liao Yuqi; Chang Sheng; Wang Changsheng; Huang Guoyong; Liu Chonghao; Zhang Deyong. A method for producing sodium phosphate from glyphosate by-product disodium hydrogen phosphate. CN201710587631.1, application date 2017 -07-18https://www.chemicalbook.com/%3C/p>
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