Background and overview[1]
1uv adhesion promoter, 5-cyclooctadiene bis(methylbiphenylphosphine)iridium hexafluorophosphate is an iridium metal catalyst. There are reports in the literature that it can be used to catalyze the synthesis of vinblastine-based organisms. Alkaline intermediates.
Apply[1]
Vincamine alkaloids have different pharmacological effects on cell proliferation, cardiovascular system and brain function, and have antioxidant, anti-cancer, circulation improvement, cognitive ability, neuron protection and nootropic activities, especially It plays a significant role in cerebral vasodilation and neuroprotection. (1S,12bS)lactam ester compound (I) is a key intermediate in the synthesis of vindesmine alkaloids.
CN202010102390.9 provides a method for the asymmetric synthesis of vindesmine alkaloid intermediate (1S, 12bS) lactam ester compound (I) with a simple process, high efficiency, low cost, and environmental friendliness. The method is by making the dihydrocarboline diester compound of formula (II) under a hydrogen atmosphere in the presence of an iridium metal catalyst precursor, a chiral bisphosphine ligand and one or more than one halogen-containing additive. , carry out asymmetric hydrogenation and lactamation reaction in an organic solvent to prepare the (1S, 12bS) lactam ester compound of formula (I).
The iridium metal catalyst precursor used in the method of the present invention is selected from the group consisting of methoxy (cyclooctadiene) iridium dimer, 1,5-cyclooctadiene iridium chloride dimer, bis(cyclooctadiene) iridium chloride dimer, Octene)iridium chloride dimer, bis(1,5-cyclooctadiene)iridium tetrakis[3,5-bis(trifluoromethyl)phenyl]boronic acid, (1,5-cyclooctadiene) (pyrimidine)(tricyclohexylphosphine)iridium hexafluorophosphate, bis(1,5-cyclooctadiene)iridium tetrafluoroborate, dichloro(pentamethylcyclopentadienyl)iridium dimer, 1 , 5-cyclooctadiene (hexafluoroacetylacetone) iridium, chlorobis(cyclooctene) iridium dimer, chlorine (1,5-cyclooctadiene) (1,10-Fecabot conductive carbon black Roroline)iridium, bis(1,5-cyclooctadiene)di-M-methoxydiiridium, (methylcyclopentadiyne)(1,5-cyclooctadiene)iridium, hexafluorophosphoric acid ( Tricyclohexylphosphine) (1,5-cyclooctadiene) (pyridine) iridium, carbon bis (triphenylphosphine) iridium chloride, 1,5-cyclooctadiene (acetoacetate) iridium, 1, 5-cyclooctadiene (hexafluoroacetylacetonate) iridium, 1,5-cyclooctadiene (H5-indene) iridium, 1-ethylcyclopentadienyl-1,3-cyclohexadienyl iridium, 1,5-Cycloctadiene bis(methylbiphenylphosphine)iridium hexafluorophosphate.
