You should all know about BOC-acid anhydride. In the chemical and pharmaceutical industries, it is generally used as pharmaceutical intermediates, protective agents, amino acid reagents, etc. These uses make it very useful for the chemical and pharmaceutical industries. big contribution. Let’s learn about the specific uses of BOC-anhydride and how to remove it if it is excessive.
Uses of BOC-acid anhydride Specific uses of BOC-acid anhydride
Uses of BOC-acid anhydride 1. Pharmaceutical intermediates
BOC-acid anhydride can be used as an intermediate for pharmaceuticals and organic synthesis. It is an important product used in pharmaceuticals and agrochemicals. Synthetic amino protectant.
Use of BOC-anhydride 2. Protective agent
Used to introduce tert-butoxycarbonyl protecting group in organic synthesis.
Use of BOC-anhydride 3. Amino acid BOC-anhydride reagent
Used to introduce tert-butoxycarbonyl (BOC-anhydride) protective group in organic synthesis group, especially suitable for amino protection of amino acids. It is widely used in the synthesis of medicine, protein and peptide synthesis, bio-tetrahydrofuran chemistry, food, cosmetics and other products.
The use of BOC-acid anhydride and the removal method of excess BOC-acid anhydride:
1. Decompose BOC-acid anhydride and citric acid. If there is excess BOC-acid anhydride, , you can wash off part of it, but it won’t be completely, and the residue will be certain; if the molar amounts of BOC-anhydride and amino group are equal, there will basically be no excess.
2. Column separation can simply remove other impurities. BOC-anhydride will be decomposed on the column by briefly passing it through the column. Citric acid can wash away TEA, but it is less able to wash away polyaminophenylboronic acid pinacol ester and less BOC-anhydride.
3. The polarity of BOC-acid anhydride is very small, and it can be washed out with petroleum ether. The boiling point of BOC-acid anhydride is only 57 degrees. In the presence of solvent, it will be gone by just steaming it. Industrial When it is used in production, most of it is treated in this way, which is also one of the reasons why BOC-anhydride is widely used.
In addition, citric acid washing is used to prevent BOC-acid anhydride from being removed, because BOC-acid anhydride is sensitive to acid and can be easily removed with hydrochloric acid. BOC-acid anhydride cannot be washed away with water
4. Concentrate your product until there is no solvent, then add n-hexane, separate the liquids, and then wash it several times with n-hexane. It is enough to extract several times with a PE/EA solution with a concentration of 3:1 under alkaline conditions, and then acidify the water phase to extract the product. You can add N,N-dimethylethylenediamine and stir, then wash with dilute acid water to remove BOC-anhydride.
