Explore how to use DMSO (dimethyl sulfoxide) How to use DMSO (dimethyl sulfoxide)
DMSO is a natural chemical originally obtained from wood. In the past 60 years, more than 40,000 articles studying this kind of DMSO have been published, but not many members of the public know about the application of DMSO in the medical and health fields. Medical treatment and health reject advertising, so unlike those ordinary mass consumer products, people can learn about related consumer products through advertising. Nitropyridine. Even in the United States, even supplementary foods placed on open shelves in supermarkets cannot spread relevant knowledge through advertising. DMSO was approved by the US FDA in 1974, but it is still used cautiously in the health and medical fields by only a small number of experts and practitioners of alternative medicine and natural medicine.
DMSO is soluble and permeable to many drugs, and it also has anti-inflammatory and analgesic effects. DMSO can promote blood circulation and wound healing, and has diuretic and sedative effects. It can increase drug absorption and improve efficacy, so it is called “panacea” abroad. Various drugs can be dissolved in DMSO and can penetrate into the body when applied on the skin without taking them orally or by injection, opening up a new way of drug delivery. More importantly, it increases the local drug content of the patient and reduces the harm of other drugs in the body. DMSO has been widely used in current external medicines such as Guyouling, athlete’s foot medicine, and hydrosone ointment, as well as external preparations in major hospitals.
There were many reports abroad about the use of DMSO for medical research in the 1960s. Some foreign studies believe that cancer cells have a protective layer of cutin, which will hinder the entry of drugs, and DMSO has the ability to dissolve and penetrate cutin, so it can improve the efficacy of tumors.
In China, academic units such as Shenyang Pharmaceutical University, Beijing Institute of Materia Medica, and China Drug Testing Center also conducted comprehensive toxicology tests and pathological anatomy in the 1960s to prove that the half-quantity LG50 value of DMSO in China is (22.4±1.4 )g/kg, which is basically consistent with the 21.4g/kg reported in foreign literature. Therefore, it is determined that DMSO is non-toxic and consistent with the pathological anatomy findings. In the 1960s, 160 medical units including Peking Union Medical College Hospital conducted clinical trials, and opened special outpatient clinics in Benxi, accumulating a large amount of data, which has been proven to be effective for neurodermatitis, psoriasis, arthritis, bursitis, folliculitis, rheumatoid, otitis media, Rhinitis, adnexitis, toothache, shingles, hemorrhoids, sprains, lumbar muscle strains, burns, trauma, etc. all have the therapeutic effect of hexahydroxypentacobalt dicarbonate. The currently produced external medicines such as Guyouling, athlete’s foot medicine, and hydrosone ointment, as well as external preparations in major hospitals, have been widely used. The Institute of Veterinary Medicine of the Chinese Academy of Sciences also uses DMSO to dissolve “Pas” to treat equine infectious anemia and parasitic diseases.
In the United States and Europe, DMSO is available as a prescription drug for clinical use and as a “solvent” of various concentrations publicly sold in supermarkets. Consumers can purchase it by themselves. It is mostly used externally to treat osteoarthritis, and often achieves good results.
The following content is compiled from “DMSO: The New Healing Power” by Morton Walker, 1983
Explore the use of DMSO (dimethyl sulfoxide) A brief history of DMSO
Dimethyl sulfoxideDMSO was discovered by Russian doctor Alexander M. Saytzeff in 1866. In the 1950s, British scientists discovered that it could be used as an antifreeze to store bone marrow and blood cells. This unique by-product of the wood pulp industry is also used as an industrial solvent and paint thinner.
In the late 1950s, Crown Zellerbach Corporation, a world-famous paper mill, asked its chemist Robert Herschler to find other uses for DMSO. After numerous experiments, Herschel discovered that DMSO mixed with certain antibiotics and antifungal agents could penetrate and enter the plant’s circulatory system. There are some chemicals that also have this ability, but DMSO is different from other chemicals in that it does not change or damage the outer protective membrane of plant cells.
After Herschel discovered that DMSO might have medicinal uses, he told his old friend Dr. Stanley Jacob, who was an associate professor of surgery at the University of Oregon at the time. Jacob specializes in cryobiology, which is concerned with freezing and preserving organs for transplantation. Due to work reasons, he knew that DMSO had anti-freezing properties, but he was very surprised that DMSO could also penetrate cell membranes. What surprised Jacob even more was that DMSO can also carry certain substances through the skin and into the blood. .
Preliminary animal experiments show that DMSO has very low toxicity. He used DMSO on himself and some people as experimental subjects, and the results showed that DMSO can quickly relieve pain, stop headaches, and even quickly recover and restore muscle sprains and burns.
The University of Oregon research grant supported further human studies, and Herschler was encouraged by the early results.
Crown Zelerbach Company applied for a medicinal patent for DMSO from the Oregon State Government, and the proposed medicinal uses are open to public review.
On December 10, 1963, the local newspaper in Portland, the capital of Oregon, listed the functions of DMSO in a front-page news article and called it a miracle drug that is good for all diseases. But the medical community demands that these new findings be published first in appropriate scientific journals, rather than in the public media.
In 1963, the FDA approved DMSO for human experiments. Some major pharmaceutical companies conducted an unprecedented number of experiments, costing a total of250 million US dollars, more than 100,000 tests, and every set of experiments shows that DMSO is a very safe and effective substance. None of the human trials have shown toxicity concerns. However, an experiment by the pharmaceutical company Merck reported that some animals receiving DMSO had some cloudy changes in the lens of their eyes. On December 25, 1965, the FDA banned all human uses of DMSO based on Merck’s research.
But research on DMSO around the world continues to show its safety. In 1967, the FDA again authorized limited human research. This year, the Vacaville study (detailed later) showed that the use of DMSO is absolutely harmless to the human eye. Based on this information and other studies, the FDA further relaxed the scope of human testing in 1968.
During this period, several pharmaceutical companies applied to the FDA to market DMSO, but all were rejected. FDA officials strongly oppose the use of DMSO. They spoke out against DMSO and its supporters. They insist that DMSO should never be marketed. As a result, many pharmaceutical companies discontinued their DMSO studies. Unfortunately, these pharmaceutical companies have published only a few thousand of the more than 100,000 research cases they have accumulated. Despite this, more than 3,000 published studies have made DMSO potentially one of the safest agents in the history of medicine.
In the mid-1970s, a Utah company finally received FDA approval to market DMSO for the treatment of interstitial cystitis.
