Application background and overview of 3-chloro-4-nitropyridine
3-Chloro-4-nitropyridine can be used as an intermediate for pharmaceutical and chemical synthesis. If 3-chloro-4-nitropyridine is inhaled, move the patient to fresh air; if there is skin contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell; if the eye contact If exposed to sunlight, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.
Applications of 3-chloro-4-nitropyridine
3-Chloro-4-nitropyridine can be used as an intermediate in pharmaceutical and chemical synthesis to synthesize other compounds with certain activity, such as the synthesis of substituted 1H-pyrrolo[3,2-b as a casein kinase inhibitor , 3,2-c and 2,3-c]pyridine-2-carboxamide and related analogs, such as the synthesis of N-[(2,5-dichlorophenyl)methyl]-4-nitro-pyridine- 3-amine, the specific synthesis steps are: add triethylamine (8.35mL, 60mmol) and (2,5-dichloro Phenyl)methylamine hydrochloride (8.5 g, 40 mmol) Tricyclohexylphosphine fluoroborate at 0°C. The reaction mixture was heated at 80°C for 1 h, then concentrated in vacuo and diluted with ethyl acetate (40 mL). The organic layer was washed with brine (2 × 20 mL), dried over anhydrous sodium sulfate, then filtered and concentrated in vacuo. The crude material was purified by column chromatography (SiO2, 1% MeOH in DCM) to give the title compound N-[(2,5-dichlorophenyl)methyl]-4-nitro-pyridin-3-amine (1.7 g , 80%). δH (MHz, CDCl3) 9.27 (s, 2H), 8.57 (br s, 1H), 8.32 (d, 1H, J6.0Hz), 7.38 (d, 1H, J 8.4Hz), 7.30-7.26 (m, 1H ), 6.60 (d, 1H, J methyltetrahydrofuran 6.0Hz), 4.64 (d, 2H, J 6.0Hz).
