Application background and overview of 3-amino-2,6-lutidine
Pyridine and its derivatives are widely distributed in nature. Many plant ingredients such as alkaloids contain pyridine ring compounds in their structures. They are the basis for the production of many important compounds, such as medicines, pesticides, dyes, surfactants, rubber additives, feed additives, food additives, adhesives, etc. Indispensable raw materials in production. 3-Amino-2,6-lutidine CAS number 3430-33-9, chemical formula C7H10N2. Molecular weight 122.16800. Density 1.039 g/c nitrite tetrafluoroborate m3, melting point 121-123°C, boiling point 230°C), flash point 230°C, refractive index 1.564. 3-amino-2,6-lutidine can be used as Pharmaceutical and chemical synthesis intermediates. If 3-amino-2,6-dimethylpyridine is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and wash the skin thoroughly with soap and water. If you feel unwell with pyridine bromide , seek medical attention; if eye contact occurs, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.
Applications of 3-amino-2,6-dimethylpyridine
3-Amino-2,6-dimethylpyridine can be used as a pharmaceutical and chemical synthesis intermediate, such as for the synthesis of 2,6-dimethyl-3-bromopyridine. 2,6-Dimethyl-3-bromopyridine is an important intermediate in organic synthesis. It is mainly used in pharmaceutical intermediates, organic synthesis, and organic solvents. It can also be used in dye production, pesticide production, and spices. At present, the reported synthesis methods of 2,6-dimethyl-3-bromopyridine have shortcomings such as low yield and long process route. Studies have provided a synthesis method of 2,6-dimethyl-3-bromopyridine with high yield, reasonable process route, and suitable for industrial production. Specifically, diethyl malonate reacts with an alkali metal to form a salt. The toluene solution of 3-nitro-2-methyl-6-chloropyridine is then added dropwise for condensation reaction, and then decarboxylated under acidic conditions to obtain 3-nitro-2,6-dimethylpyridine; 3-nitro-2 , 6-dimethylpyridine is catalyzed by Pd/C, methanol is used as the solvent, hydrogenated and reduced, suction filtrated, and the filtrate is concentrated to obtain 3-amino-2,6-dimethylpyridine; 3-amino-2,6- Dimethylpyridine first forms a salt with acid, cools to -10℃-0℃, adds liquid bromine dropwise, and adds subaqueous solution dropwise after the dropwise addition. After the dropwise addition is completed, adjust the pH of the solution to alkaline, and then extract, dry, and concentrate to obtain 2,6-Dimethyl-3-bromopyridine. The molar ratio of diethyl malonate, alkali metal, and 3-nitro-2-methyl-6-chloropyridine is 5-6: 1.1-1.3:1. The alkali metal is selected from metal sodium and metal potassium. The method has mild reaction conditions, high yield, easily available raw materials, low cost, short process route, and has industrial prospects.
Application and preparation of 3-amino-2,6-dimethylpyridine
3-Nitro-2,6-dimethylpyridine is catalyzed by Pd/C and methanol is used as a solvent, hydrogenated and reduced, filtered, and the filtrate is concentrated to obtain 3-amino-2,6-dimethylpyridine. .
