Background and overview[1-3]
Deuterated toluene is a chemical substance commonly used as an internal standard. It can also be used as an intermediate to prepare other deuterated compounds.
The chemical formula is C7D8. English name: TOLUENE-D8. CAS number: 2037-26-5. Molecular weight: 100.19. LogP: 1.99500. Appearance and properties: colorless liquid.
Used as an intermediate[3]
Junk et al. reported the preparation of deuterated benzothiazole compounds using deuterated toluene.
Used as internal standard[1-2]
CN201910272382 discloses a method for detecting menthol in a heat-not-burn core base material, which belongs to the technical field of analytical chemistry. First, weigh 0.5g-1.0g of the heat-not-burn core substrate sample and place it in a brown headspace bottle, add the internal standard deuterated toluene, quickly seal the bottle cap, and analyze by HS-SPME-GC/MS. According to the internal standard method Quantitative. The present invention fills the gap in the measurement of menthol in the base material of heat-not-burn cigarette cores. It uses deuterated toluene as an internal standard and adopts the HS-SPME-GC/MS method to measure the menthol in the base material of heat-not-burn cigarette cores. The detection overcomes the problem that the base material of heat-not-burn cigarette cores has complex components and many interfering substances, making it difficult to directly and accurately measure the menthol of the existing conventional methods; it also avoids the existing conventional methods that have many pre-processing steps, resulting in menthol Alcohol loss problem. The method is simple, fast, has low detection limit, good precision, accuracy and reliability, and is easy to promote and apply.
CN201410856746 protects a method for determining the content of chloromethyl ether in automotive materials. The determination steps are: 1) Cut the sample to be tested into a small cube with a size of about 2 mm × 2 mm × 2 mm, and seal it Set aside; 2) Weigh a certain amount of sample into a headspace bottle, add acetone, and then add deuterated toluene as an internal standard, cap the bottle tightly and place it in the headspace sampler 3) Use gas chromatography-mass spectrometry The instrument determines the content of chloromethyl ether in the sample. The present invention adopts headspace sampling technology and gas chromatography mass spectrometry to measure the content of chloromethyl methyl ether in automobile materials, and the internal standard method is used for quantification. The measurement method has a small sampling amount, simple pre-processing operation, fast testing, and can realize For the accurate determination of chloromethyl methyl ether in automotive materials, the detection limit of this method is 100 mg/kg.
Main reference materials
[1] CN201910272382.6 A method for detecting menthol in the heat-not-burn core substrate
[2] CN201410856746.2 A method for determining chloromethyl methyl ether in automotive materials
[3] Junk T , Catallo W J , Civils L D . Synthesis of polydeuterated benzothiazoles via supercritical deuteration of anilines[J]. Journal of Labeled Compounds, 1997, 39(8):625-630.
