Background and overview[1]
Ethylene glycol monoallyl ether is a colorless and transparent liquid with a faint characteristic odor. It is easily miscible with water and will oxidize slightly when exposed to the air for a long time. Because the molecular formula contains hydroxyl and double bonds, it is a new type of environmentally friendly polymerized monomer and intermediate. Because of its high boiling point and low odor, it is suitable as a comonomer for the synthesis of resins containing hydroxyl functional groups and as a modified intermediate for silicone. . It can replace allyl alcohol and has excellent performance. Mainly used in the production of fluorocarbon resins, super absorbent resins, unsaturated polyesters, light-cured coatings, water-soluble coatings, additives for paints and plastics, stabilizers for polyurethane foam, solid polymer electrolytes for batteries and chromium plating, etc. At present, there are two synthesis process routes for ethylene glycol monoallyl ether: 1) etherification end-capping method. Allyl chloride is used to perform hydroxyl etherification with ethylene glycol under alkaline conditions, and then purified by distillation. This method will produce a large amount of inorganic salts, and the excess allyl chloride is difficult to recover and can easily cause pollution to the environment. 2) Polymerization method. Propylene alcohol and ethylene oxide undergo ring-opening polymerization under an alkaline catalyst and then undergo distillation and purification. This method easily produces by-products polyethylene glycol and allyl polyethylene glycol ether with a polymerization degree of ethylene oxide above 1.
Apply[2-6]
Ethylene glycol monoallyl ether, as a comonomer of fluorine coating-fluorocarbonate resin, can adjust the hardness of the coating film and impart hydrophilicity to the fluorine resin. With the development of fluorine coatings, ethylene glycol monoallyl ether as a reactive diluent has been widely used.
1) Prepare a kind of graphene, including the antistatic agent Irgastat P18 as follows: 1) prepare graphene oxide; 2) use a silane coupling agent to modify graphene oxide; 3) use the silane coupling agent obtained in step 2) In the presence of coupling agent-modified graphene oxide, an initiator is added to copolymerize N-vinylpyrrolidone and polyethylene glycol monoallyl ether to obtain a silane coupling agent-modified graphene oxide dispersion with the copolymer as the dispersant. ; 4) Add gallic acid and tannic acid to the modified graphene oxide dispersion obtained in step 3) to perform a reduction reaction to obtain the final product graphene. The graphene has biological application prospects and can form stable, high-concentration dispersions.
2) Prepare a sustained-release material containing diclofenac sodium, which is made from the following raw materials by weight: 55-65 parts of diclofenac sodium, polylactic acid/alginic acid co-modified polyethylene glycol monoallyl ether- [3-(methacrylamido)propyl]dimethyl(3-thiopropyl)ammonium hydroxide inner salt-oleylamine polyoxyethylene (2) ether copolymer 20-25 parts, diclofenac sodium quaternary ammonium Salt – 105-10 parts, oxidized paraffin/polyvinyl alcohol co-modified attapulgite 1-3 parts, glycerol 1-3 parts, hypromellose 0.1-0.3 parts, water 5-10 parts. The invention also discloses a preparation method of the sustained-release material containing diclofenac sodium. The sustained-release material containing diclofenac sodium disclosed by the invention has more significant curative effect, better sustained-release performance, good stability and acid and alkali resistance, and is safer and more environmentally friendly to use.
3) Preparing a ceramic water-reducing agent, including the following steps: (1) N-[β-(N, N-acetoxy)aminoethyl]-γ-(N-acetoxy)aminopropyl Trimethoxysilane modified polyethylene glycol monoallyl ether; (2) based on 1-(2-(4-aminophenyl)ethyl)amino-1-(hexaglucosyl)deoxysorbitol Preparation of 15 types of polymerized monomers of quaternary ammonium salts; (3) polymerization; (4) sodium adenosine phosphate modified octa(6-bromo-6-deoxy)-γ-cyclodextrin; (5) water reducing agent preparation. The ceramic water-reducing agent disclosed in the invention has strong versatility, is imported from Germany in small quantities, has significant water-reducing and dispersing effects, has good chemical and thermal stability, and has strong hydration ability.
4) Prepare an application for treating rheumatism, including a heating composition and a functional composition that are provided separately from the heating composition. The heating composition and functional composition are respectively provided on two independent breathable films. In the bag, the two independent breathable film bags are connected by an adhesive layer; the functional composition includes the following components by weight: polyethylene glycol monoallyl ether Tween co-modified porous Ge -10-20 parts of Se-Fe-O, 80-90 parts of Chinese herbal extract. The rheumatism-treating patch disclosed by the invention has the advantages of convenience, safety, good rheumatism-treating effect, small side effects, good breathability, significant drug transdermal effect, short treatment course, and high cure rate.
Preparation[1]
Using 1-chloropropene, ethylene glycol [2], potassium hydroxide and other main raw materials and catalyst A to react at a certain temperature and pressure to obtain a crude product, which is then crudely steamed and special distilled to obtain the product. Optimal material ratio (molar ratio): 1-chloropropene: ethylene glycol: potassium hydroxide = 1:2:1; (2) Optimal reaction conditions: temperature 75~85°C; pressure 0.16~0.18Pa.
1) Main reaction: 1-chloropropene reacts with ethylene glycol and potassium hydroxide under the action of catalyst A
Into ethylene glycol monoallyl ether.
2) Side reactions:
Hydrolysis of 1-chloropropene to allyl alcohol
Generate ethylene glycol diallyl ether
Ethylene glycol diallyl ether and allyl alcohol can be suppressed to an acceptable level by controlling the reaction conditions.
Main reference materials
[1] Synthesis of ethylene glycol monoallyl ether
[2] Development of ethylene glycol monoallyl ether
[3] CN201510536582.X Graphene and its preparation method
[4] CN201910061372.8 A sustained-release material containing diclofenac sodium andIts preparation method
[5] CN201811132558.X Preparation method of ceramic water-reducing agent
[6] CN201910081813.0 A compress for treating rheumatism
