Cyclic adenosine-3,5′-mconophosphate (CAMP), as a derivative of nucleotides, is the earliest intracellular messenger discovered and has been proven to deliver nitrogen-containing hormones in the human body. It is also a protein kinase inhibitor and is classified as a “second messenger”.
Mechanism of action
Although cyclic adenosine monophosphate plays an important role in regulating cell metabolism and many physiological effects , but there are also some limitations in its clinical application. For example, it is difficult to penetrate the cell membrane and is easily hydrolyzed by intracellular phosphodiesterases. Therefore, the structure of CAMP needs to be modified and transformed to eliminate the above shortcomings. For example, two butyryl groups are added to the cyclic adenosine monophosphate molecule to form dibutyryl cyclic adenosine monophosphate to enhance its fat solubility, so that it can smoothly pass through the cell membrane and play a role in the cell, and then convert into CAMP in the cell, thereby activating Protein phosphorylase enhances myocardial function, improves peripheral vascular circulation, eliminates the inhibition of insulin secretion during shock, promotes the absorption of sugar by tissue cells, and improves the body’s energy metabolism; at the same time, it can also resist phosphodiesterase in the body The degradation of CAMP makes the action time more lasting and rapid, so it has broader market and application prospects.
Technical Features
This synthesis process has made significant improvements on the basis of the current production process and separation process. Its main advantages include:
1. No reaction required Preparation of quaternary ammonium salt intermediates completely eliminates the use of protective agents and acid binding agents.
2. Through the improvement of new separation technology and equipment, the generation of pungent odors such as butyric acid during the production process has been effectively solved, the separation process has been greatly simplified, and the separation yield has been significantly improved.
3. Through route design, the co-production process of high-value butyric acid-derived chemicals is realized, which greatly improves the atom economy of the entire reaction process.
Through the above improvements, the synthesis route and post-processing process have been greatly simplified, the production cycle has been shortened, product quality has been significantly improved, environmental protection and protection issues during the reaction process have been effectively solved, and scaled-up production can easily be achieved. It is conducive to reducing enterprise production costs, increasing product competitiveness, and achieving good economic and social benefits.
Applications
Calcium dibutyryl cyclic adenosine monophosphate can treat various diseases caused by G protein dysfunction. It is mainly used clinically for the treatment of angina pectoris and acute myocardial infarction. It can also be used for It can be used to treat myocarditis, cardiogenic shock, post-operative subretinal hemorrhage and psoriasis. It can also be used as an auxiliary anti-cancer drug for clinical treatment of leukemia, etc. In addition, it has an important impact on animals maintaining the normal function of their immune system, gastrointestinal tract development, liver function, lipid metabolism, etc. It has obvious effects in promoting animal growth and improving meat quality in livestock production.
