Tilmicosin is one of the most common macrolide antibiotics used in breeding production; later, scientists obtained tilmicosin by reacting phosphoric acid and water with tilmicosin base Tilmicosin phosphate. Currently, tilmicosin phosphate preparations can also be seen on sale in the veterinary drug market.
As a result, some netizens who are sensitive to these two drugs sometimes send messages asking “What is the difference between tilmicosin and tilmicosin phosphate?” Since it is the end of the year and there are many things to deal with, here I will just briefly talk about them. difference between.
First of all, judging from the raw powder properties of these two drugs, normal tilmicosin is mostly white or off-white powder; while tilmicosin phosphate is slightly darker in color, often light yellow powder.
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Secondly, the solubility of these two drugs is different. Tilmicosin is almost insoluble in water, while tilmicosin phosphate is soluble in water. In routine physical and chemical laboratories, the difference can be detected.
Thirdly, the molecular formulas, molecular structures and molecular weights of the two drugs are different. The molecular formula of tilmicosin is C46H80N2O13, and the molecular weight is 869.13; the molecular formula of tilmicosin phosphate is C46H80N2O13.H3PO4, and the molecular weight is 967.14.
Fourthly, the effective contents of the two drugs are different at the same mass. The effective content of tilmicosin is not less than 85%, while the effective content of tilmicosin phosphate is usually above 75%. Its content can be detected by high performance liquid chromatography.
Fifth, the pH of the solutions in which these two drugs are dissolved in water is different. For conventional physical and chemical laboratories, only a pH meter is needed to perform this test.
Sixth, the charges and amounts of charge of the two drugs in solutions, digestive juices, and tissue fluids are different, which can also be detected through in vitro simulations.
Seventh, there is a difference in the fat solubility of these two drugs. The lipid solubility of tilmicosin is much higher than that of tilmicosin phosphate. This difference can also be detected in conventional physical and chemical laboratories.
Eighth, the lipid-water partition coefficients of these two drugs are different. In conventional physical and chemical laboratories, the fat solubility and water solubility of these two drugs can be measured and their lipid-water partition coefficients can be calculated respectively.
Ninth, the oral absorption speed and degree of absorption of these two drugs are different. Friends who have the conditions and are interested can do the oral administration test on relevant target animals (this may be a little more troublesome than the above-mentioned detection tests).
In short, tilmicosin and tilmicosin phosphate are two different drugs. They have the same characteristics as Tosoh macrolide antibiotics, but also have different characteristics. Those who use tilmicosin phosphate as a substitute It is wrong to regard Mikao Xing as a substitute for Mikao Xing.
