Background and overview[1]
Creatinine is a cyclic structure formed by condensation of creatine by removing a molecule of water. It is a kind of metabolic waste excreted through the blood and urine, and becomes a component of non-protein nitrogen (NPN) in blood and urine. Its daily output is generally very constant. Normal adult men excrete 20 to 26 mg of creatinine in urine per kilogram of body weight every day, and normal adult women excrete about 14 to 22 mg. The concentration of creatinine in blood Clariant dye is 88 to 177 μmol/L (1 to 2 mg/dl). The creatinine content in blood and urine is mainly determined by the total body muscle mass. In addition, in cases of fever, diabetes, hyperthyroidism and various muscle diseases, due to enhanced decomposition of muscle tissue, creatinine excretion increases. Furthermore, since the creatinine filtered by glomerular surfactant is not reabsorbed at all and is excreted outside the body, renal function can be measured by creatinine clearance. Creatinine phosphate is a high-energy substance that releases about 1.5 times the energy of ATP. The direct energy supply substance in the body is ATP, and the energy released by ATP can be converted into ADP. At this time, through the action of creatine kinase, creatine phosphate quickly supplies ADP with a phosphate group and generates ATP, thus restoring normal ATP levels. After creatine phosphate loses its phosphate group, it can be phosphorylated by ATP to regenerate creatine phosphate.
Apply[1]
Creatinine phosphate and its salts can be used to synthesize creatine phosphate and its salts. For example, creatinine phosphate disodium is dissolved in water, decolorized with activated carbon in an ice water bath, filtered, ethanol is added to the filtrate, and creatinine phosphate disodium is obtained by suction filtration. Sodium refined product: Dissolve the prepared disodium creatinine phosphate refined product in water, add activated carbon, stir in an ice water bath, filter, add sodium hydroxide to the filtrate to adjust the pH of the solution to 13-14, stir, and then in an ice water bath Use hydrochloric acid to adjust pH to 7-10, decolorize with activated carbon at room temperature, filter, add ethanol to the filtrate, continue stirring, and obtain disodium creatine phosphate by suction filtration; dissolve the prepared disodium creatine phosphate in water, add activated carbon, and stir. Filter, add ethanol to the filtrate, continue stirring, and obtain refined disodium creatinine phosphate by suction filtration; the advantage is that impurities produced during the preparation of disodium creatinine phosphate can be removed to the greatest extent.
Main reference materials
[1]Hygiene Dictionary
[2] CN200810032884.3 Synthesis method of creatine phosphate disodium salt
