Overview
Compound Butasfos Injection is currently the only endogenous anti-stress drug that can improve animal stress response, promote metabolism and enhance immunity. It is safe, efficient, residue-free, and does not produce harmful substances in the body. It has many advantages such as drug resistance. It causes the least damage to the individual body and has the fastest onset of effect. Its administration route is more suitable for stress treatment and prevention of pigs, cattle, sheep, poultry, etc. under intensive breeding mode. , as well as energy nutrition preparations for special animals such as dogs and pigeons.
Compound butalifos injection is a water-soluble sterilizing preparation prepared by mixing butalifos and vitamin B12. Among them, Butasfos is an effective organophosphorus supplement. Vitamin B12 can improve the metabolism of proteins, carbohydrates and fats, and increase the synthesis of red blood cells. The combined application of the two can improve energy utilization and regulate trace element imbalances.
Clinical Application
1. Application of butafosate in anti-stress
The heat stress response refers to the total response of the body to any requirements put forward by the thermal environment when the body is in a high temperature environment, and is mainly characterized by an increase in the synthesis of heat shock proteins (HSPs). A series of highly programmed processes triggered within the cells of an organism play a role in protecting the outcome of stress. Studies have shown that heat stress can cause disorders in the body’s respiratory, digestive, circulatory, endocrine and immune system functions, such as accelerated breathing and heart rate, and increased body temperature.
Scientists have studied animals such as sheep and cattle under high temperature stress and found that butafosate can prevent reduced feed intake, slowed weight gain, reduced heartbeats, accelerated breathing, and cortisol caused by heat stress. Secretion is reduced and can inhibit antibody-dependent cytotoxicity induced by thermal stimulation. Hasssurong et al. used yellow-feathered broilers as the research object to detect the changes in various indicators before and after the action of butafos. The results showed that butaphos can exert its anti-stress effect by adjusting some hormone contents in the serum of broiler chickens and changing some serum biochemical indicators. effect.
Currently, the anti-stress effect of butaphos is widely used, such as when beef cattle enter the housing or are regrouped. Butafos helps cope with stress, enhance immunity and other performance parameters, making beef cattle faster adapt to the new environment. In addition, butafosate has a good relieving effect on horses that are under high stress during competition and can prevent horses from premature fatigue. In China, Vietnam and South Korea, butasfosate is mainly used to resist high temperature stress, transportation stress, cow birth stress, etc., and has achieved ideal results.
2. Application of butafosate in energy metabolism and immunity
In addition to improving the body’s endurance, Butasfosate can also increase the body’s liver glycogen and muscle glycogen reserves, promote the synthesis of adenosine triphosphate (ATP) and adenosine diphosphate (ADP), and increase energy charge. As well as affecting the ultrastructure and quantity of mitochondria to enhance the energy metabolism of the animal body. Since the liver and muscles are the direct tissues for energy storage and utilization of the body, the oxidative utilization of glycogen is the main form of energy supply for metabolism and exercise. Therefore, it is of great significance to enhance metabolism and extend exercise time through the use of certain drugs, and butafosate can increase the content of ATP and ADP by increasing the body’s glycogen reserves, thus anti-fatigue and improving energy charge. effect.
Studies have shown that Butafoso injection can improve the cold resistance, heat resistance and hypoxia resistance of mice, significantly extend the load swimming time of mice, and can also significantly increase the contents of liver and muscle glycogen, as well as liver tissue and The content of ATP and ADP in muscle tissue has no significant effect on the adenosine monophosphate (AMP) content in liver tissue, but it has a certain reducing effect on the AMP content in muscle tissue. In 2011, E. M． Research by Hanafi and others shows that the application of butaphos in suckling piglets is mainly manifested in its ability to significantly increase the weight of piglets, enhance the energy metabolism of pigs, and promote newborn piglets to obtain sufficient milk.
The function of butafosate in body immunity is to enhance the body’s immunity by enhancing the body’s non-specific defense function, specific cellular immune response and specific humoral immune function. Specific performance: Butasfosate not only enhances the resistance of the animal body, but also increases the phagocytic index of phagocytes and the content of serum hemolysin, thus improving the humoral immunity and the percentage of CD4+ and T lymphocytes and the ratio of CD4+/CD8+ .
Some scholars have studied the changes in the immune function of mice after using compound butaphosphorus. Compound butaphosphos can increase the phagocytic index and hemolysin content of mononuclear macrophages, and the test group increased by 4% compared with the negative control group. -5 times, 2.7-3.5 times higher than the positive control group. Cows 7 weeks before giving birth were given subcutaneous injections of 20 mL butasfosate every 3 weeks, and the immunoglobulin content in the colostrum was detected. The results showed that the IgG and IgA levels in the test group were higher than those in the control group. Therefore, in clinical practice, butafosol injection can be used as an auxiliary treatment for many diseases with low immunity caused by bacterial infections.
3. Application of butaphos in animal fertility
At present, in the cattle breeding industry, there are mainly restrictive problems such as reproductive dysfunction, mastitis and birth syndrome mainly due to metabolic diseases. Such problems have blocked the smooth development of the dairy industry. Butapfosin injection is effective for…It has a good regulatory effect on physiological stress states such as metabolic disorders, reproduction, pregnancy, delivery and lactation of cattle and has become a research hotspot. For example, injecting butaphos before and after delivery in dairy cows can significantly stabilize the fluctuation of serum aspartate aminotransferase content, preventing it from increasing due to delivery, reducing the incidence of reproductive failure syndrome, and at the same time shortening the calving interval without affecting milk production. , thereby improving economic efficiency.
Studies have found that compound butafosol injection can reduce metabolic disorders in dairy cows by 80%. Compared with cows that did not use compound butafosul injection, the probability of ovarian dysfunction, convulsions and acetonuria was reduced by 22% after use. The incidence of infertility and uterine disease in the control group was higher than that in the compound butafoso injection treatment group. 2-4 times higher respectively.
In pig production, butafosate is mainly used for sow metritis, mastitis, agalactia syndrome, piglet weaning stress and group transfer stress, low feed intake, poor growth and development, and low libido of male animals. Prevention and treatment of other diseases. The use of butaphos during the peripartum period of sows can effectively prevent obstetric diseases, shorten the labor process, promote estrus and the discharge of afterbirth. If used in conjunction with antibiotics, it can also effectively prevent birth canal infections. This is a drug widely used in foreign dairy cows and sows during the peripartum period. The most important reason for Talfos Injection. In our country, many pig farms use intramuscular injection or intravenous infusion of Cortex to prevent obstetric diseases and restore the physical fitness of sows during delivery, so that the sows can eat as soon as possible after delivery.
4. Applications of butasfos in other aspects
Butasfos Injection can also enhance chicken metabolism, promote anabolism and growth of chicks, increase egg production rate, and enhance stress and disease resistance. That is to say, injecting butaphos into laying hens can increase the egg production rate of UV adhesion promoter to 90%, and the quality of eggshells is also significantly improved. Butafosin injection can also increase the weight gain rate of broiler chickens by 8.62%, improve feed return rate, and prevent broiler chicks from pecking each other’s anuses and feathers. At the same time, Butafoso injection can improve the quality of meat by repairing muscle cells and tissues, and can accelerate the regeneration of damaged skeletal muscle.
Studies have shown that injecting piglets with butaphos and cobalamin can promote phagocytosis and cell proliferation, thereby accelerating the regeneration of damaged skeletal muscle. For example, using butafos solution in broiler chickens can stimulate the growth of breast and leg muscles. The specific performance is that the weight of leg muscles and vulcanized breast muscles of broilers in the test group are 23.9% and 24.7% higher than that of the control group. In order to solve the problem that Nile tilapia requires a lot of energy during the spawning season and has high mortality during early development, injecting a certain amount of butafosin injection into Nile tilapia can improve the spawning rate and reproductive performance, and can also Reduces mortality, increases metabolic activity and induces growth of pups. Therefore, the difficulties of fish farming are solved to a large extent.
