Background and overview[1]
Prednisolone Sodium Phosphate, English name: Prednisolone Sodium Phosphate; Prednisoline 21-Phosphonic Acid Disodium Salt, CAS number: 125-02-0, EINECS number: 204-722-9.
The clinical uses of prednisolone sodium phosphate are: as an adrenocortical hormone drug, it has various pharmacological effects such as anti-inflammatory, anti-allergic and immune suppression. Anti-inflammatory effect: Glucocorticoids reduce and prevent tissue responses to inflammation, thereby reducing the manifestations of inflammation. Immunosuppressive effects: Prevent or inhibit cell-mediated immune responses, delay allergic reactions, and reduce the expansion of primary immune responses. Anti-toxic and anti-shock effects: Glucocorticoids can resist the stimulating response of bacterial endotoxins to the body, reduce cell damage, and play a role in protecting the body.
Preparation[1]
CN201310539987.X provides a production process for prednisolone sodium phosphate.
Saturated polyester
The production process of prednisolone sodium phosphate provided by the invention includes using prednisolone phosphate as raw material and includes the following steps:
(a) Dissolve prednisolone phosphate with methanol, add purified water after dissolution, add sodium hydroxide solution dropwise into the tank for reaction, control the temperature during the dropping process to 15-30°C, and slowly adjust the pH value to 9.2-10, stir, retest the pH value and then filter;
(b) Add ethanol to the dilution tank, add the filtrate after the reaction in step (a), stir to precipitate a large number of crystals, let it stand for at least 8 hours, then discharge the material, wash the material with ethanol and dry it to obtain prednisone Sodium phosphonate, the number of milliliters of methanol used in step (a) is 4-5 times the grams of prednisolone phosphate, and the number of milliliters of purified water added is 4-6 times the grams of prednisolone phosphate, In step (a), the pH value is slowly adjusted to 9.5. In step (b), the number of milliliters of ethanol added to the dilution tank is 15-30 times the number of grams of prednisolone phosphate.
The beneficial technical effects of the production process of prednisolone sodium phosphate provided by the present invention are: the process route is simple, the conditions are mild, the raw materials are easily available, the separation is easy, the cost is low, and it can obtain pharmaceutical-grade products that meet pharmaceutical grade requirements. Prednisolone Sodium Phosphate.
Apply[2-3]
1. Used to prepare an insulating and highly flame-retardant cable sheath material
CN201610113926.0 An insulating and highly flame-retardant cable sheath material, including the following components by weight: 50-70 parts of polyolefin elastomer, 20-35 parts of polytetrafluoroethylene, and 10-15 parts of dioctyl ester , 8-14 parts of dibutyl phthalate, 12-18 parts of prednisolone sodium phosphate, 15-20 parts of diphenyl phosphate azide, 5-13 parts of magnesium 3-picolinate, 3-aluminum naphthenate 9 parts, fly ash 20-30 parts, guaifenesin 15-25 parts, vinyltrichlorosilane 3-10 parts, methylaluminoxane 9-13 parts, 2-camphenone 4-9 parts.
The preparation method includes the following steps:
S1: Combine 50-70 parts of polyolefin elastomer, 10-15 parts of dioctyl ester, 12-18 parts of prednisolone sodium phosphate, 15-20 parts of diphenyl azide phosphate, and 3 parts of aluminum naphthenate -9 parts and 3-10 parts of vinyltrichlorosilane are mixed in a high-speed mixer for 1-2 minutes, and then mixed, plasticized and granulated by a twin-screw granulator;
S2: Add 20-35 parts of polytetrafluoroethylene, 8-14 parts of dibutyl phthalate, 20-30 parts of fly ash and 15-25 parts of guaifenesin into the reaction kettle at a temperature of 60- Mix at 80℃ for 20-40min;
S3: Add the product obtained in step S2 to step S1, first react at a temperature of 80-90°C for 20-30min, and then stir rapidly at a speed of 500-650r/min for 10-15min; then extrude through an extruder It is discharged, cooled, and granulated by a single-screw granulator to obtain the cable sheathing material.
The preparation method of an insulating high flame-retardant cable sheath material according to the present invention uses polyolefin elastomer and polytetrafluoroethylene as the main body, and adds prednisolone sodium phosphate, diphenyl azide phosphate, 3-Magnesium picolinate, aluminum naphthenate, fly ash, guaifenesin, vinyltrichlorosilane, methylaluminoxane and 2-camphenone make the cable sheathing material obtained have high flame retardant properties. The combustion distance is short and the self-extinguishing time is fast; the preparation process is simple and easy to operate.
2. Used to prepare a modified fly ash water purification material
Fly ash mainly refers to the fine ash collected from the flue gas after coal combustion. It is one of the main solid industrial wastes discharged from coal-fired power plants. The rapid development of the electric power industry has led to an increase in fly ash emissions from coal-fired power plants year by year. If a large amount of fly ash is discharged into the water system, it will cause river siltation and even cause harm to the human body and organisms. In addition, fly ash can be used as concrete of admixtures. Although there have been reports on using fly ash as a water purification material, the hardness of the existing materials prepared from fly ash is weak and the adsorption pores are not uniform enough, which affects the adsorption effect of metal ions during the wastewater treatment process. CN201610269386.5 provides a modified fly ash water purification material and a preparation method thereof. The modified fly ash water purification material prepared by this method has the advantages of strong hardness, uniform pore distribution, and good metal ion adsorption effect. Technical solution: a modified fly ash water purification material, including the following components by weight: 20-30 parts of fly ash, 10-15 parts of diatomite, 12-18 parts of sodium metasilicate, and hexafluorosilicone 8-12 parts of barium acid, 5-10 parts of dimagnesium trisilicate, 2-6 parts of prednisolone sodium phosphate, 1-6 parts of sodium tripolyphosphate, 10-16 parts of 4-methylsalicylic acid, 4 -Methoxybutyric acid 6-15 parts, 2-ethyl-2-amino-1-propanol 14-20 parts. Preparation method, including the following steps:
S1: Add 20-30 parts of fly ash to 4-AAdd 10-16 parts of base salicylic acid and stir for 10-15 minutes;
S2: Add 12-18 parts of sodium metasilicate, 8-12 parts of barium hexafluorosilicate and 1-6 parts of sodium tripolyphosphate into step S1, raise the temperature to 40-45°C, and stir for 5-10 minutes , obtain mixture A;
S3: Add 10-15 parts of diatomaceous earth, 5-10 parts of dimagnesium trisilicate and 2-6 parts of prednisolone sodium phosphate to 6-15 parts of 4-methoxybutyric acid, and raise the temperature to 60-80°C and stir for 10-20 minutes to obtain mixture B;
S4: Mix 14-20 parts of mixture A described in step S2, BASF pigment B and 2-ethyl-2-amino-1-propanol described in step S3, and set the temperature to 80-100°C , let the reaction stand for 20-30 minutes; and then the modified fly ash water purification material can be obtained after drying and granulation.
The preparation method of a modified fly ash water purification material according to the present invention is by adding modified diatomite to the treated fly ash, stirring, heating, impregnation and other processes A modified fly ash water purification material is prepared; compared with simple fly ash material, the water purification material has stronger hardness and uniform pore distribution, and has an obvious effect of removing metal ions in sewage.
Main reference materials
[1] CN201310539987.X A production process of prednisolone sodium phosphate
[2] CN201610113926.0 An insulated and highly flame-retardant cable sheath material and its preparation method
[3] CN201610269386.5 A modified fly ash water purification material and its preparation method
