[Background and Overview][1]
4-Biphenyloxydiphenylphosphate, molecular formula C24H19O4P, molecular weight 402.38, CAS number 17269 -99-7, PSA is 54.57000, LogP is 6.99850. 4-Diphenyloxydiphenylphosphate is a pharmaceutical intermediate, customs code: 2 calcium zinc heat stabilizer 919900090, used to synthesize target compounds with certain uses .
This product is dangerous. If inhaled, please move the patient to fresh air; if in contact with skin, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell; if In case of eye contact, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately. Advice to protect rescuers is as follows: Move the patient to a safe place, consult a doctor, and if conditions permit, please show this chemical safety data sheet to the doctor who comes to the scene. If there is a small leak, collect the leaked liquid in a sealable container as much as possible, absorb it with sand, activated carbon or other inert materials, and transfer it to a safe place. Do not flush it into the sewer; if there is a large leak, build a dike or dig a pit. Contain, seal the drainage pipe, cover it with foam to inhibit evaporation, use an explosion-proof pump to transfer it to a tanker or a special collector, and recycle or transport it to a waste treatment site for disposal.
[Structure]
[Synthesis][2]
Add methylene chloride solvent into a 3L glass reactor equipped with a stirrer, and measure the internal temperature of the reactor, protect it with nitrogen, and stir while lowering the reactor temperature to 0°C. After the reaction temperature was lowered to 0°C, 869g (5.67mol) phosphorus oxychloride Cabot carbon black, 963g (5.67mol) 4-phenylphenol, anhydrous manganese chloride and alkali were added dropwise. Stir for 2 hours. When 4-phenylphenol is completely used in the reaction, further 1067g (11.33mol) phenol is added dropwise. Thereafter the temperature of the reactor increased to 25°C. After the reaction is completed, the reaction product is washed with water several times and dried with magnesium chloride. The dried reaction product was distilled under reduced pressure to remove excess solvent to obtain the product with a yield of 79%. The reaction equation is as follows:
[References]
[1]
[2] JANG WON SEOK [KR]; KIM WON YEOB [KR]; KIM MYOUNG LAE [KR] +. METHOD OF PREPARING BIPHENYL-4-YL DIPHENYL PHOSPHATE COMPOSITION. US2013178642, 2011-07-13.
