Polyene Phosphatidylcholine
[Overview][1][2][3] Polyene Phosphatidylcholine
) is a Western medicine preparation that can be made into various preparations with a variety of pharmaceutical excipients and is mainly used for auxiliary treatment of liver disease. After the drug enters the human body, it is directly absorbed through the first-pass effect of the liver. It has a good absorption effect. It enters the liver cells and combines with the liver cell membrane as a complete molecule. It can also be secreted as bile. It has the function of repairing liver function and enzyme activity, regulating liver balance, promoting liver regeneration, assisting in the conversion and transport of fat and cholesterol in the liver, and achieving the purpose of stabilizing bile. In addition, it also has certain effects on liver damage, psoriasis, and radiation syndrome caused by pregnancy. It has been included in medical insurance and is a Class B drug.
【Introduction】[1][2]
English name: Polyene Phosphatidylcholine
Chinese name: polyene phosphatidylcholine.
Alias: Painate, Yi Shanfu, Essentiale Forte N.
Molecular weight: 800 (average molecular weight).
Composition: Natural polyene phosphatidylcholine, with a large number of unsaturated fatty acid groups, mainly linoleic acid (about 70%), linolenic acid and oleic acid.
Structural formula:
[Pharmacological effects] [1] This product is a complex of high-carbon polyenoyl lecithin and choline chloride. It has the effects of protecting the liver, strengthening the liver, promoting lipid metabolism and fighting fatty liver. When suffering from liver disease, the metabolic activity of the liver is severely damaged. Polyene phosphatidylcholine can provide high-dose, high-energy polyene phosphatidylcholine that is easily absorbed and utilized. In terms of chemical structure, polyene phosphatidylcholine is consistent with important endogenous phospholipids. It mainly enters liver cells and The intact molecule binds to liver cell membranes and organelle membranes; in addition, it can also enter bile. Therefore, polyene phosphatidylcholine has the following effects: restoring damaged liver function and enzyme activity to normal by directly affecting the membrane structure, regulating the energy balance of the liver, promoting liver tissue regeneration, and converting neutral fat and cholesterol into easily metabolized form, stabilizing bile.
The average plasma concentration of this product reaches 20% 6 to 24 hours after oral administration. The half-life of choline is 66 hours, and the half-life of unsaturated fatty acids is 32 hours. The excretion rate in feces after oral administration does not exceed 5%.
[Indications] Various types of severe liver diseases, such as acute jaundice hepatitis, chronic persistent hepatitis and active hepatitis, hepatic necrosis, cirrhosis, hepatic coma (including prodromal hepatic coma), lipoplastic antistatic agent fatty liver (also known as fatty liver disease) Seen in patients with diabetes), bile obstruction, liver poisoning, to prevent the recurrence of gallstones; treatment before and after surgery, especially hepatobiliary surgery, and pregnancy; it can also be used for vomiting, psoriasis, neurodermatitis, and radiation syndrome.
[Medication Guide] 1. The capsules of this product should be taken whole with plenty of liquid after meals. 2. For intravenous injection, only clear solutions should be used. Do not mix with any other injection. 3. During intravenous injection, it is strictly forbidden to dilute with electrolyte solution (such as 0.9% sodium chloride solution, Ringer’s solution, etc.). 4. During intravenous injection or intravenous drip treatment, if the condition permits, the patient should try to take this product orally at the same time to enhance the curative effect. 5. If the patient misses one dose, he or she can take it the next time he takes the medicine; if he misses one dose, he does not need to take it again. 6. Depending on the severity of the condition, the treatment course may last up to 1 year.
[Dosage and Usage][1] ①Oral administration: Unless otherwise specified by the doctor’s prescription, it should be taken according to the following dosage plan. Adults should start with 2 capsules (456 mg) each time, 3 times a day, and the maximum dosage should not exceed 6 capsules (1368 mg) daily. After a period of time, it can be reduced to 1 capsule (228 mg) each time, and the maintenance dose is 3 times a day. Tablets should be swallowed whole with plenty of liquid after meals. The dosage for children should be reduced.
②Injection: It can be injected intravenously or intravenously. It can only be diluted with glucose injection (5% or 10%) and 5% xylitol injection. It is forbidden to dilute with 0.9% sodium chloride injection and Ringer’s injection. . The daily dose for adults is 232.5-456 mg, and in severe cases it can be increased to 456-930 mg per day.
【Precautions】 ① It is prohibited for those who are allergic to this product. ②Diarrhea may occasionally occur when using large doses. If you forget to take a dose, you can double the dose the next time you take it; if you forget to take one day’s dose, you don’t need to take another dose, but you should take the next day’s dose. ③ This injection is prohibited for newborns and premature infants. ④A very small number of patients may have an allergic reaction to the benzyl alcohol contained in Rohm and Haas resin. ⑤The injection should be a clear solution and should be administered slowly during intravenous injection.
【Adverse reactions】[4]
1. Gastrointestinal discomfort, diarrhea, etc. may occasionally be seen when increasing the oral dose.
2. A very small number of patients may have allergic reactions to the benzyl alcohol in this injection.
【Taboo】
1. Those who are allergic to any component of this product.
2. This injection is prohibited for newborns and premature infants.
[Drug interactions] are not clear yet.
【Preparation specifications】[4][5] Capsules: 228 mg. Injection: 5 ml: 232.5 mg.
[References]
[1] Chen Jisheng, editor-in-chief. New Edition of Clinical Pharmacology. Beijing: China Traditional Chinese Medicine Press. 2013.
[2] Liu Fuqiang et al. Editor-in-Chief. Physician’s Desk Medication Reference. Beijing: China Traditional Chinese Medicine Press. 2012. [3] Zhang Fukang Editor-in-Chief.�Formulary of Commonly Used Drugs in Hospitals. Nanjing: Southeast University Press. 2012.
[4] Yang Daming, editor-in-chief. Clinical Medication Quick Reference Manual. Nanjing: Jiangsu Science and Technology Press. 2005.
[5] Xu Jingfeng, Yang Benming, editors-in-chief. Clinical Prescription Drug Handbook. Nanjing: Jiangsu Science and Technology Press. 2009. Pages 474-475.
