Methylpyridinate is an acaricide with insecticidal activity. It is a contact and gastric poison. It has good long-lasting effect and a broad insecticidal spectrum. It can be used in cotton, fruit trees, vegetables and livestock, public health and households to prevent and control various mites, moths, aphids, leaf lice, small heartworms, potato beetles, flies, cockroaches, etc. This agent has low toxicity to humans and animals and is highly effective and A safe agent with low toxicity and low residue, it is an organophosphorus pesticide recommended by the World Health Organization (WHO). It can be made into emulsions, sprays, powders, wettable powders and soluble granules (Fangchenin), etc. Among them, picolinate granular poison bait is particularly suitable for controlling flies and other hygienic pests.
【Character】
This product is a white or off-white crystalline powder with an odor, slightly soluble in water, and easily soluble in methanol, methylene chloride and other organic solvents.
【Function and use】
This product is a new type of organophosphorus pesticide with high efficiency and low toxicity. Mainly stomach poison, it also has contact killing effect, killing adults of flies, cockroaches, ants and some insects. Because the adults of these insects have the habit of licking constantly, drugs that work through stomach poison are more effective. If combined with an attractant, the ability to attract flies can be increased by 2 to 3 times. With a one-time spray according to the specified concentration, the reduction rate of flies can reach 84% to 97%. Picolinate also has a long residual effect. Apply it on cardboard and hang it in the house or stick it on the wall. The residual effect can be 10 to 12 weeks. Spray it on the wall and ceiling and the residual effect can be 6 to 8 weeks.
Animals absorb almost all of picoline after ingestion. Twelve hours after oral administration to goats, 76% of the drug was excreted in urine, 5% in feces, and 0.5% in milk. Residues in tissues are low, 0.022 mg/kg in muscle and 0.14-0.4 mg/kg in kidneys; hens take 5 mg/kg medicated feed, and the residual amounts after 22 hours are 0.1 mg/kg in blood and 0.6 mg in kidneys. /kg. It can be seen that the drug remains very little in meat, fat, and eggs, and there is no need to specify a drug withdrawal period. In addition to adult flies, this product also has a good killing effect on cockroaches, ants, fleas, bed bugs, etc. It is mainly used to kill adult flies in thermoplastic elastomers such as stables and chicken coops; it is also used to kill flies and cockroaches in homes, restaurants, food factories and other places.
【Usage and Dosage】
Picolinate granules: Spread where adult flies and cockroaches gather, and concentrate 2g per square meter.
Methylpyridine wettable powder: Spray, make a 10% suspension with water, and spray 50ml per square meter on the floor, walls, ceilings, etc. To apply, use 100g of wettable powder containing picolinate (10%), add 80ml of water to make a paste, and apply a dot (approximately 13cm × 10cm) every 2m2 on the floor, wall, ceiling, etc.
【Preparations and Specifications】
Picolinate granules: 100g, containing 1g of active ingredient; picolinate wettable powder: containing 10% picolinate and 0.05% inducer.
【Notes】
(1) This product is of low toxicity. The LD50 for oral administration is 1.18g/kg in rats and 1.4g/kg in mice. It is slightly irritating to the eyes. Although animals can stay in the stables during spraying, they cannot be sprayed directly on animals. , the feed should also be moved elsewhere.
(2) This product is highly toxic to salmon and slightly toxic to other fish. Do not pollute rivers, ponds and sewers during use. It is also toxic to bees and should not be used in areas with dense bee colonies.
(3) The medicine should be diluted with water and used within the same day. After the suspension is left for 30 minutes, it should be stirred evenly before use.
[Content determination] Dimethicone emulsion
High performance liquid chromatography.
Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel (Nucleosil) is used as the filler, and the detection wavelength is 280nm. Use gradient elution with mobile phases A and B. The elution procedure is:
Time (minutes) 0 15 17 21 23 30
Mobile phase A% 100 100 0 0 100 100
Mobile phase B% 0 0 100 100 0 0
Mobile phase A is acetonitrile-methanol-0.1% phosphoric acid (1:3:6)
Mobile phase B is acetonitrile-0.1% phosphoric acid (9:1)
Measurement method: Take about 50 mg of this product, weigh it accurately, put it in a 50 ml measuring bottle, add 25 ml of acetonitrile to dissolve, add 15 ml of water, add 5 ml of potassium hydrogen phthalate buffer (0.05 mol/L, pH 4.0), and dilute with water to the mark, shake well; accurately measure 5 ml, place it in a 25 ml volumetric flask, and dilute to the mark with potassium hydrogen phthalate buffer (0.05 mol/L, pH 4.0)-acetonitrile-water (1:4:5) , shake well, accurately measure 10 μl and inject it into the liquid chromatograph, record the chromatogram; take another reference substance of picolinate, and measure it in the same way. It is calculated by the peak area according to the external standard method.
