Background and overview[1-2]
1,2-Dioleoyl-SN-glycerol-3-phosphorylethanolamine, DOPE (dioleoylphosphatidylethanol Rohm and Haas resin amine), is the most commonly used auxiliary lipid. Oleoylphosphatidylcholine) and CHO (cholesterol) liposomes have high fusion and transfection efficiency. Among the commercialized cationic liposomes, most use DOPE as an auxiliary lipid.
Apply[1-2]
Application 1,
CN201910428250.8 provides a nanoparticle composition delivery system, preparation method and use, belonging to the field of nanobiomaterials. The delivery system includes anti-tumor drugs, GAPDH-siRNA and cationic liposomes; anti-tumor drugs and GAPDH- siRNA is co-loaded in cationic Lomon titanium dioxide R996 liposomes; among them, the raw materials for cationic liposomes include 2-dioleoylhydroxypropyl-3-N,N,N-trimethylammonium chloride, plant sterols, Diacetone-D-galactose and 1,2-dioleoyl-SN-glycerol-3-phosphorylethanolamine. The preparation method includes: preparing cationic liposome raw materials and anti-tumor drugs into cationic liposomes loaded with anti-tumor drugs; mixing the cationic liposomes loaded with anti-tumor drugs and GAPDH-siRNA to prepare a nanoparticle composition delivery system. The delivery system of the present invention has the advantages of high encapsulation rate, good stability, large loading capacity of drugs and genes, small change in particle size, and high cell uptake efficiency and uptake rate.
Application 2,
CN201380075820.0 provides a new delivery method that can effectively deliver active ingredients to target cells. A liposome for topical administration, which is composed of 1,2-dioleoyl-SN-glycerol-3-phosphorylethanolamine (DOPE), phosphatidylcholine and cationic lipids, is not modified by PEG, and Contains no cholesterol.
References
[1] CN201910428250.8 Nanoparticle composition delivery system, preparation method and use
[2] CN201380075820.0 Liposome for topical administration and its use
