Organozinc compounds refers to a class of organic compounds containing carbon-zinc chemical bonds. OrganozincChemistry is a discipline that studies the physical and chemical properties, synthesis and reactions of organozinc compounds.
The first organozinc compound discovered and prepared was diethylzinc. It was also the first compound discovered to have a metal-carbon@ bond. Many organozinc compounds are flammable and difficult to handle (most organic solvents are also flammable and present a safety hazard). Most organic zinc compounds are easily oxidized and will decompose when dissolved in protic solvents. In the hemopolymer reaction, Organozinc reagents need to be prepared and used immediately and cannot be separated, purified or stored for too long. All reactions using organozinc reagents need to be carried out under the protection of an inert gas, such as nitrogen or argon.
The most common oxidation state of organozinc compounds is +2. It can be divided into three types: organic zinc halides; dialkyl zinc compounds; lithium acid acid salts or magnesium zinc acid salts.
Due to the different electronegativities of the carbon and zinc elements: the polarity of the carbon-zinc chemical bond points toward the carbon atom. Dihydrocarbyl zinc compounds usually exist in monomeric form, while organozinc halide compounds can form polymeric forms through halogen bond bridges, which are similar to the Schlenk equilibrium of Grignard century and Grignard reagents.
The following are some synthetic Organozinc compounds Method:
Oxidative addition. Diethylzinc, which was first discovered by Frank Land, was prepared by this method: under the “protection” of hydrogen, the addition reaction of ethyl iodide and elemental zinc was carried out. The activity of metallic zinc can be enhanced by the zinc reagent, which is obtained by the reduction reaction of potassium metal and zinc chloride.
Halide-zinc exchange. This method is mainly divided into two types: iodine-zinc exchange and boron-zinc exchange. The first step in the second reaction is the hydroboration of the olefin.
Metal transfer. In a typical metal transfer reaction, diphenylmercury and zinc elements react in diethyl ether to obtain diphenylzinc and metallic mercury. The reaction speed is very slow and takes two weeks.
Organic zinc compounds It can also be obtained directly from metallic zinc.
